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Your Heart, Our Mission

Chronic angina: a hidden cost

CorCMR Study

Microvascular Angina frequently diagnosed as Non-cardiac Chest Pain - Big Implications for overall Chronic Angina Prevalence

In a conversation with Uwe Tigör, Chief Medical Officer of Auxilius Pharma, Prof. Colin Berry, a cardiology and imaging specialist from the University of Glasgow, discusses the results of the CorCMR study, presented at the American Heart Association Scientific Sessions. The study focuses on the diagnosis of patients presenting with chest pain.

CorCMR

The Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging Trial

Click on the image to watch the full interview

Chronic stable angina

most often occurs on the background of atherosclerotic coronary artery disease

Current angina treatments are either poorly suited or even contraindicated in patients with significant bradycardia or heart block, as many anti-anginal drugs, such as beta-blockers or non-dihydropyridine calcium channel blockers, may exacerbate these conditions.

1. Marinescu et al. JACC Cardiovasc Imaging. 2015;8(2)210-220. 2. Patel MR et al. N Engl J Med. 2010;362:886-95. 3. Bradly C, Berry C. J Nucl Cardiol. 2022;29;1763-75. 4. Taqueti VR, Di Carli MF. J Am Coll Cardiol. 2018;72(21):2625-2641. 5. Chen JW et al. Am J Cardiol. 1997;80;32-38. 6. Zhu H et al. Clin Ther. 2019;41(10)2137-2152. 7. Kaski JC et al. Circulation. 2018;138;1463-1480. 8.Knuuti, J et al. Eur Heart J. 2020;41,:407-477

three types of coronary artery disease

Chronic stable angina

is a highly prevalent condition taking a heavy toll on millions of people

It is the symptomatic side of coronary artery disease (CAD), typically manifesting as chest pain and shortness of breath

Chronic stable angina affects 11 million Americans over the age of 20
Experience angina symptoms five years after diagnosis despite optimal treatment
Lifestyle, longevity and life-saving cardiovascular procedures contribute to a growing stable angina population
Report daily or weekly symptoms despite taking multiple antianginal medications

Our solution - AUX-001 - effective angina symptom-controlling agent

with proven hospitalization reduction effect

Auxilius Pharma is actively working on introducing AUX-001 to key markets worldwide as a first-line medication, taken once daily, based on well-established, long-term efficacy and safety results of the active ingredient nicorandil.

An efficient antianginal agent with a unique mechanism of action, able to address both macro and microvascular angina
First US anti-angina agent which controls chronic angina symptoms AND reduces cardiovascular risk and frequency of hospitalization
Convenient once-daily dosing with no risk of tachyphylaxis (drug tolerance) frequently observed with long-acting nitrates

Interviews with US commercial payors indicated their willingness to reimburse AUX-001 given its hospitalization reduction effect